9/11/2023 0 Comments How to find serum serial numberHowever, there is currently no approved vaccine against SUDV, although several vaccine candidates were demonstrated to protect laboratory animals against the disease in preclinical studies 6, 7, 8, 9, 10. Biomedical Advanced Research and Development Authority (BARDA) which goals include having a monovalent SUDV vaccine in the next decade 5. As such, development of safe and efficacious vaccines is a high priority for the WHO and the U.S. The extremely high case fatality rate, the significant transmissibility of SUDV and its potential use as a biological warfare and bioterrorism weapon underscore the importance of countermeasures against this virus. Since its discovery in 1976, SUDV triggered eight outbreaks that infected 779 people and killed 412 people – 53% of infected people the virus is responsible for the greatest number of ebolavirus outbreaks after EBOV 4. Recently, two vaccines against the deadliest of these viruses, EBOV, were approved for human use: Ervebo VSV-based vaccine 2, as well as Zabdeno (Ad26.ZEBOV) and Mvabea (MVA-BN-Filo) heterologous prime/boost vaccine 3. Several filoviruses are responsible for fatal outbreaks of severe human diseases: Ebola virus (EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV) and Tai Forest virus (TAFV) 1.
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